Vaccine-induced immune tolerance is a phenomenon where a vaccine modifies the immune system’s reactivity to specific antigens, leading to a reduced immune response upon repeated exposure. This tolerance can be beneficial, especially in cases of autoimmune diseases, where excessive immune activity needs to be curtailed to prevent damage to the body’s own tissues. Some therapeutic vaccines aim to induce immune tolerance to specific self-antigens, thereby helping patients with conditions like multiple sclerosis or type 1 diabetes. In such contexts, vaccines are designed to 'teach' the immune system to tolerate these self-antigens, reducing the risk of autoimmune flare-ups. However, inducing tolerance poses challenges for infectious disease vaccines, as unintended tolerance to pathogenic antigens could decrease vaccine efficacy, making it critical to carefully design and evaluate vaccines to ensure the desired immune response is achieved.
Khursheed Anwer
IMUNON, United States
Ping Xie
Rutgers University, United States
Regina Au
BioMarketing Insight, United States
Madhu Khanna
University of Delhi, India
Lara Isis Teodoro
Mayo Clinic, United States
Ahmed Abdulazeez
BHRUT Trust, United Kingdom
Elena Chiappini
University of Florence, Italy
Ayesha Zahid
Griffith University, Australia
Livia Daflon Silva
Federal University of State of Rio de Janeiro, Brazil
Neha Bhandari
Chitkara University, IndiaSubmit your abstract Today
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