Vaccine-induced immune tolerance is a phenomenon where a vaccine modifies the immune system’s reactivity to specific antigens, leading to a reduced immune response upon repeated exposure. This tolerance can be beneficial, especially in cases of autoimmune diseases, where excessive immune activity needs to be curtailed to prevent damage to the body’s own tissues. Some therapeutic vaccines aim to induce immune tolerance to specific self-antigens, thereby helping patients with conditions like multiple sclerosis or type 1 diabetes. In such contexts, vaccines are designed to 'teach' the immune system to tolerate these self-antigens, reducing the risk of autoimmune flare-ups. However, inducing tolerance poses challenges for infectious disease vaccines, as unintended tolerance to pathogenic antigens could decrease vaccine efficacy, making it critical to carefully design and evaluate vaccines to ensure the desired immune response is achieved.
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Title : Tubercular disease in children: Optimizing treatment strategies through disease insights
Elena Chiappini, University of Florence, Italy
Title : Prophylactic and Molecular Approaches for Mitigating Human Influenza A Viruses: i. Evaluating influenza Vaccine Effectiveness in the Older population ii. Down-regulation of influenza virus genes with novel siRNA-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Title : The role of immunity in the pathogenesis of SARS-COV-2 and in the protection generated by COVID-19 in different age groups
Ahmed Abdulazeez, BHRUT Trust, United Kingdom
Title : Development of a Novel Multi-component Vaccine to Address the Burden of Otitis Media in High-Risk Populations
Ayesha Zahid, Griffith University, Australia
Title : Targeting resistance: New 4-substituted pyrazolidine and isoxazolidine as antibiotics with interesting antimicrobial activities
Yousfi Tarek, Nationale Research for Biotechnology Research Center, Algeria
Title : Racial disparities in pediatric pneumonia in Brazil: The role of structural racism forging inequalities in acess to vaccines
Livia Daflon Silva, Federal University of State of Rio de Janeiro, Brazil
Title : Immunosuppression in COVID-19 Patients and Emerging Fungal Infections: Vaccines, Diagnosis and Strategies to Treat Comorbidities
K R Aneja, Kurukshetra University, India
Title : Immunogenicity and Cryo-EM structure of native-like HIV-1 Clade-C envelope trimers derived from a pediatric elite-neutralizer
Swarandeep Singh, All India Institute of Medical Sciences, India
Title : Why is the vaccine life-threatening if people get a fever after a COVID-19 vaccination
Yacob Mathai, Marma Health Centre, India
Title : Barriers to polio eradication in South Asia: A systematic review
Awranoos Ahadi, Bolan Medical College, Pakistan