A critical leap in immunization strategies involves optimizing how antigens reach immune cells, and novel vaccine delivery systems are making this possible. Nanoparticles, microneedles, viral-like particles, and lipid-based carriers are among the innovative platforms reshaping delivery routes. These technologies offer enhanced stability, targeted cellular uptake, and controlled antigen release—minimizing dosage while maximizing immune activation. Intranasal, oral, and transdermal methods are being refined to improve patient compliance and eliminate the need for cold chain logistics. Researchers are also investigating self-amplifying RNA and implantable delivery devices for long-lasting immunity. The convergence of materials science and immunology is creating systems that go beyond injection-based models, with implications for both human and veterinary medicine. As regulatory bodies adapt to these innovations, Novel Vaccine Delivery Systems are poised to redefine the speed, accessibility, and efficacy of global immunization programs.
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Title : Emerging nanovaccine strategies for enhanced immune targeting and vaccine performance
Aysel Sadayli, V.Y. Axundov Scientific-Research Institute of Medical Prophylaxis, Azerbaijan
Title : Reaching zero-dose children through adaptive immunization strategies in security-compromised areas of Zamfara State, Nigeria
Attahir Abubakar, Ahmadu Bello University, Nigeria
Title : Advancing vaccine availability and equity in low-resource settings: Evidence from Awendo Sub-County, Kenya
Millicent Ochieng, Clinton Health Access Initiative, Kenya