Nanoscopic structures are small vehicles for delivery of vaccines or drugs that are measured in nanometers and best visualized by electron microscopy. An example of the first approved human nanoscopic vaccine was Dr. Jonas Salk’s formalin inactivated polio vaccine. The [....] » Read More
Why is Post-Marketing Surveillance and Real-World Data important for the success of your product? Post-Marketing Surveillance or Phase IV is required by the FDA after the product is approved and launched. Phase IV is mainly focused on pharmacovigilance, drug safety an [....] » Read More
This study aims to review the available data regarding the central role of immunity in combating SARS-CoV-2 infection and in the generation of protection by vaccination against COVID-19 in different age groups. Physiologically, the immune response and the components involved in i [....] » Read More
Vaccines have long been credited as the most effective tool in preventing and managing infectious diseases. They have drastically reduced the global disease burden. Over the years, significant progress has been made in understanding the immune system and developing novel vaccine [....] » Read More
This paper reports the development and expression of a DNA vaccine targeting WT1overexpressed in many solid and hematologic tumors. This vaccine incorporates immunogenic epitopes, guaranteeing broad demographic representation (99.26.26% worldwide and 98.37% in Mexico) via promine [....] » Read More
Porcine epidemic diarrhea virus (PEDV) continues to cause substantial economic losses in the global swine industry, highlighting the urgent need for rationally designed attenuated vaccines. This study systematically characterizes specific virulence-attenuating mutations in both t [....] » Read More
The incidence of fungal infections, called mycosis, has dramatically increased in COVID-19 patients with predisposing factors. COVID-19, not over and still circulating worldwide, is a respiratory illness caused by strains of coronavirus SARS-CoV-2 (severe acute respiratory syndro [....] » Read More
The persistent global demand for safer, more effective, and rapidly scalable vaccine platforms has driven innovations beyond traditional formulations. Exosomes, a class of nanosized extracellular vesicles (EVs), represent a revolutionary approach owing to their inherent biocompat [....] » Read More
If the body becomes inflamed after consuming a substance, our immune system tells us that the substance is against the body. If the substance further increases inflammation, reduces blood flow, and affects organ function, the substance is life-threatening. Vaccination [....] » Read More
The rapid rise of emerging pathogens highlights the critical need for accelerated vaccine design approaches that integrate computational vaccinology, advanced immunoinformatic and scalable production platforms. Drawing from India’s successful COVID-19 response and polio era [....] » Read More
This 22-month cohort study investigated the durability and dynamics of humoral immune responses in 327 Malaysians vaccinated with either CoronaVac or BNT162b2 in early 2021, monitored up to 52 weeks following a BNT162b2 booster. Using the ImmuSAFE™ COVID+ microarray, we eva [....] » Read More
Recently, multi-drug resistant (MDR) bacteria are responsible for a large number of infectious diseases that can be life-threatening. Globally, new approaches are targeted to solve this essential issue. This study aims to discover novel antibiotic alternatives by using the whole [....] » Read More
Background/Introduction: COVID-19’s pandemic has had a catastrophic global impact, with nearly one billion reported infections and seven million deaths worldwide. By the middle 2020, several studies described the so-called long COVID syndrome as an emerging and prevale [....] » Read More
In recent years, the extracellular vesicles have been used as theranostics in different pathological conditions. Extracellular vesicles include different subsets such as exosomes (these are the smallest of the extracellular vesicles, ranging from 30-150 nm in diameter. They origi [....] » Read More
Background: In Cameroon, vaccination coverage remains below national and global targets, partly due to missed opportunities for vaccination (MOV) and delays in timely immunization. While household surveys such as the Multiple Indicator Cluster Survey (MICS) provide valuable [....] » Read More
Since the outbreak of COVID-19 in December 2019, no global consensus treatment has been developed and generally accepted for the disease. However, eradicating the disease will require a safe and efficacious vaccine. In order to prepare for the eventual development of a safe and e [....] » Read More
SYN023 is a mixture of two anti-rabies humanized monoclonal IgG1κ antibodies which bind to distinct and non-overlapping antigenic sites on the rabies virus glycoprotein. Updated spectrum of neutralization studies and epitope mapping analyses will be discussed. A [....] » Read More
Introduction: Despite the critical importance of complementary feeding, large proportions of children in developing countries are sub-optimally fed during 6–23 months of age. In Ethiopia, even though the government has been rolling out infant and young child feeding (IYCF) [....] » Read More
Background: Monkeypox, an emerging Orthopoxvirus, is transitioning from zoonotic spillovers to sustained human-to-human transmission in dense urban environments, posing threats to global health. In 2019, Lagos State—Africa’s largest megacity—experienced a m [....] » Read More
Background: In high-burden settings like Nigeria, maternal Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) infections pose serious risks to pregnancy outcomes and neonatal health. Both are blood-borne, vaccine-preventable diseases with overlapping transmission [....] » Read More
Background: Zero-dose children, those who have never received a single vaccine represent the sharpest edge of immunization inequity worldwide. In Lagos, Nigeria’s megacity of over 15 million, high-density settlements, complex migration patterns, population fluidity, and fra [....] » Read More
Title : A promising novel approach to DNA vaccines
Khursheed Nadeem Anwer, IMUNON, United States
Nucleic acid-based vaccines (mRNA or DNA) present a promising alternative to traditional vaccines due to their ability to induce both humoral and cellular immune responses. While mRNA vaccines have been recognized for their ability to provide efficient protection, concerns remain [....] » Read More
Title : Prophylactic and molecular approaches for mitigating human influenza A viruses: i. Evaluating influenza vaccine effectiveness in the older population ii. Down-regulation of influenza virus genes with novel sirna-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Influenza viruses continue to cause severe emerging and remerging outbreaks worldwide. Recent viral pandemics of the 2009 [pandemic influenza A (H1N1)] and 2019 (SARS-CoV-2), have enhanced the need of vigilance for combating such emerging and re-emerging viral outbreaks and mitig [....] » Read More
Title : Commensal bacteria drive B-cell lymphomagenesis in the setting of innate immunodeficiency
Ping Xie, Rutgers University, United States
Myeloid cells are central players in innate immunity and inflammation. Their function is regulated by the adaptor protein TRAF3. We previously reported that aging myeloid cell-specific TRAF3-deficient (M-Traf3-/-) mice spontaneously develop chronic inflammation and B-cell lymphom [....] » Read More
Title : Establishing a platform method for physical appearance assessment of new parenteral pharmaceuticals
Ying Wan, Merck & Co., United States
Physical appearance (PA) is an attribute indicating the quality of parenteral pharmaceuticals. It is routinely evaluated during release and stability testing and included in regulatory filings. PA assessment of liquids involves three tests: visible particulates, clarity, and colo [....] » Read More
Title : Evaluating the immunogenic impact of process impurities in mRNA vaccine production: Establishing integrated control strategies and specifications
Jesse Kuiper, Merck Research Laboratories, United States
The advent of mRNA vaccines has revolutionized the landscape of immunization, particularly highlighted during the COVID-19 pandemic. It is well known that the production process for these vaccines can introduce various impurities, such as endotoxins, double-stranded RNA (dsRNA), [....] » Read More
Title : New biomarkers in leishmania major vaccine development
Negar Seyed, Pasteur Institute of Iran, Iran (Islamic Republic of)
Leishmaniasis (a sandfly0borne disease) is caused by the unicellular parasite from Leishmania genus and is already a major thread in tropical and subtropical regions of the world but the distribution map could shift to other regions due to climate change. Unfortunately, no vaccin [....] » Read More
Title : Transforming vaccines access through cost-efficient last-mile delivery models in LMICs
Jeniffer N Adungosi, Clinton Health Access Initiative – Global Vaccines Delivery, Kenya
Background: In low? and middle?income countries (LMICs), persistent vaccine stockouts at the last mile hinder routine immunization (RI) coverage and exacerbate zero?dose burdens, particularly in hard?to?reach areas. Traditional ‘pull’ distribution models often requir [....] » Read More
Title : Mpox vaccination in Africa: One year on – lessons and milestones from the continental response
Charles Ugochukwu Ibeneme, Africa Centers for Disease Control and Prevention(Africa CDC), Ethiopia
Introduction: Mpox, long endemic in Central and West Africa, re-emerged as a continental threat during 2022–2024, with over 45,000 cases and nearly 1,500 deaths across 12 countries. The surge in Clade Ib cases in DRC and beyond led Africa CDC to declare a Public Health Em [....] » Read More
Title : Overcoming biophysical characterization challenges of small antigens in dilute vaccine formulations
Eric Kemp, Merck & Co., United States
The large-scale manufacturing of vaccines is a complex series of steps that demands significant effort in process, formulation, and analytical development. One notable challenge in the vaccine manufacturing process is aggregation. Interfacial & shear stress, freeze/thaw [....] » Read More
Title : A combined LC-MS and immunoassay approach to characterize preservative-induced destabilization of human papillomavirus virus-like particles adsorbed to an aluminum-salt adjuvant
Ria T Caringal, University of Kansas, United States
During the multi-dose formulation development of recombinant vaccine candidates, protein antigens can be destabilized by antimicrobial preservatives (APs). The degradation mechanisms are often poorly understood since available analytical tools are limited due to low protein conce [....] » Read More
Title : Development of a broad-spectrum vaccine against enterovirus based on adenovirus expression viral-like particles
Yen Hung Chow, National Health Research Institutes, Taiwan
We study a potent valent vaccine based on adenovector expressing enterovirus A71 (EV-A71) viral like particle (AdVLP) which elicits a multivalence against not only EV-A71 but also other coxsackieviruses such as A10. In young-aged human scavenger receptor class B, member 2 – [....] » Read More
Title : Establishment of a high-throughput fluorescent antibody-to-membrane antigen assay to measure the humoral immune response against the varicella-zoster virus
Junmei Zhang, WuXi AppTec, China
Keywords: varicella-zoster virus (VZV), fluorescent antibody-to-membrane antigen (FAMA), high content screening (HCS) Varicella-zoster virus (VZV) is a highly contagious alpha-herpesvirus that infects more than 90% of people worldwide. Primary VZV infection results in Chicke [....] » Read More
Title : Awareness and acceptability of rotavirus vaccine among mothers of under-five children in Gusau and Bungudu communities of Zamfara State, Northwestern Nigeria
Attahir Abubakar, Ahmadu Bello University, Nigeria
This study examines the awareness and acceptability of the rotavirus vaccine among mothers of children under five in Gusau and Bungudu, Zamfara State, Nigeria. Employing a comparative cross-sectional design, the research utilized quantitative surveys and qualitative focus groups [....] » Read More
Title : Exploring a novel interaction between the human malaria parasite plasmodium vivax and reticulocyte protein
Manish Tripathi, All India Institute of Medical Sciences, India
The global burden of malaria remains significant despite concerted elimination efforts, with Plasmodium vivax presenting unique challenges due to its distinctive biology and invasion mechanisms. Despite progress in understanding Plasmodium falciparum, the molecular interactions g [....] » Read More