Genomics, proteomics, and systems biology in vaccinology offer a multidimensional view of host-pathogen interactions, enabling the design of more effective vaccines. Genomic sequencing helps identify conserved genes and virulence factors, while proteomic analysis reveals expressed antigens suitable for immune targeting. Systems biology integrates these layers, mapping complex immune networks and signaling pathways in response to vaccination. These insights allow researchers to predict immunogenicity, design personalized vaccines, and discover novel biomarkers for efficacy assessment. High-throughput screening platforms and computational modeling are bridging molecular discoveries with translational outcomes. As the field embraces precision vaccinology, genomics, proteomics, and systems biology in vaccinology are paving the way for next-generation immunization strategies with broad and lasting protection.
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