Enhancing immunogenicity without compromising safety is a central goal in modern immunoprophylaxis, and vaccine adjuvants and immunomodulators play a pivotal role in achieving it. These agents stimulate, direct, or modulate the immune response to improve vaccine efficacy, particularly in populations with weaker immunity such as the elderly or immunocompromised. From aluminum salts to saponin-based formulations and Toll-like receptor agonists, the landscape of adjuvants is expanding rapidly. Immunomodulators further fine-tune responses by influencing cytokine profiles, antigen presentation, and T-cell polarization. Beyond boosting responses, they contribute to dose sparing and cross-protection against antigenic variants. Safety profiling, compatibility with different antigen types, and long-term immunological outcomes remain critical aspects of ongoing research. As global attention shifts toward adaptable platforms, Vaccine adjuvants and immunomodulators are becoming integral to the success of next-generation vaccines addressing complex and evolving disease threats.
Duccio Medini
BioForge, United States
Jocelyn Jakubik
Apex Pathogen Solutions, United States
Sergey V Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Rosane Cuber Guimaraes
Bio-Manguinhos/ Fiocruz, Brazil
Zhujun Ao
University of Manitoba, Canada
Sergey V Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Ashish Kumar Maurya
John Snow India, India
Sajal Dey
BRIC-Centre for DNA Fingerprinting and Diagnostics, India
Ayman H M El Deeb
Cairo University, EgyptSubmit your abstract Today
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