The structural design of vaccines focuses on understanding and manipulating the three-dimensional structure of pathogens or their components to create more effective vaccines. By analyzing the structure of proteins or antigens, researchers can determine which parts of the pathogen are most likely to trigger a strong immune response. This understanding is essential for designing vaccines that can precisely target these key structures, leading to a more effective and specific immune response. Advanced technologies such as cryo-electron microscopy and X-ray crystallography have allowed scientists to visualize the atomic structure of viral proteins in unprecedented detail. This has led to breakthroughs in the design of vaccines that target specific components of pathogens, such as spike proteins in the case of SARS-CoV-2. Structural vaccinology also helps in designing subunit vaccines, which contain only parts of a pathogen, reducing the risk of adverse reactions while maintaining efficacy.
Title : Prophylactic and molecular approaches for mitigating human influenza A viruses: i. Evaluating influenza vaccine effectiveness in the older population ii. Down-regulation of influenza virus genes with novel sirna-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Title : Homology analysis of MPXV and VACV peptides underscores the need to consider both MPXV clades for vaccine development
Lara Isis Teodoro, Mayo Clinic, United States
Title : Development of a novel multi-component vaccine to address the burden of otitis media in high-risk populations
Ayesha Zahid, Griffith University, Australia
Title : High seroprevalence of RSV antibodies in adults indicates potential undetected transmission and requires further public health assessment
Lara Isis Teodoro, Mayo Clinic, United States
Title : The role of immunity in the pathogenesis of SARS-COV-2 and in the protection generated by COVID-19 in different age groups
Ahmed Abdulazeez, BHRUT Trust, United Kingdom
Title : New biomarkers in leishmania major vaccine development
Negar Seyed, Pasteur Institute of Iran, Iran (Islamic Republic of)
Title : Tubercular disease in children: Optimizing treatment strategies through disease insights
Elena Chiappini, University of Florence, Italy
Title : Approaches towards developing and establishing a biomanufacturing research & development, and manufacturing industry in Zimbabwe: A review of the need, potential funding sources, policy development and implementation
Elliot Nyagumbo, Midlands State University, Zimbabwe
Title : Racial disparities in pediatric pneumonia in Brazil: The role of structural racism forging inequalities in acess to vaccines
Livia Daflon Silva, Federal University of State of Rio de Janeiro, Brazil
Title : Capillary electrophoresis for adjuvanted multivalent recombinant vaccine purity determination
Ashley Prout, Merck, United States