New innovative technology platform has creating the next generation of DNA or RNA vaccines based on the genetic code of the pathogenic agents. Drug delivery systems are come up with technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to upgrade health condition and increase lives. Technological advances in immunology, protein design, and genetic delivery have unlocked new possibilities for vaccine concepts and delivery technology that were previously inaccessible. The most important requirements are a vaccine should be safe and efficacious can be restated as a formulation that it is made with the appropriate potency that persists over the duration of conditions until it is administered to the patient.