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Adjuvants in Vaccine Development

Adjuvants are critical components in vaccines, added to enhance the immune response, making vaccines more effective with smaller antigen doses. By stimulating the innate immune system, adjuvants attract immune cells to the injection site and promote a more robust adaptive immune response. Common adjuvants include aluminum salts, which are widely used, as well as newer formulations like MF59, an oil-in-water emulsion. Adjuvants allow vaccines to achieve protective immunity more efficiently, especially in populations with weaker immune responses, such as the elderly or immunocompromised individuals. This enhancement not only increases vaccine efficacy but also supports the development of vaccines against complex pathogens. As adjuvant research advances, new formulations could potentially make vaccines more accessible and effective worldwide, especially in settings with limited healthcare resources.

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