Viral gene evolution is a dynamic process characterized by the continuous adaptation and modification of viral genetic material over time. This phenomenon is driven by several factors, including natural selection, genetic mutations, and recombination events, resulting in the diversity of viral populations. Mutations in viral genes occur as a natural consequence of viral replication, with some mutations conferring advantages, disadvantages, or neutral effects on viral fitness. Positive selection favors mutations that enhance viral replication, transmission, or evasion of host immune responses. Recombination, where genetic material from different viruses combines, further contributes to viral gene evolution. This process can lead to the emergence of novel viral strains with unique genetic compositions and potentially altered biological properties. Selective pressures, such as host immune responses and antiviral interventions, play a crucial role in shaping viral gene evolution. Rapid evolution allows viruses to evade immune recognition and develop resistance to antiviral drugs. Understanding viral gene evolution is essential for designing effective vaccines and antiviral strategies. Ongoing research explores the molecular mechanisms driving viral evolution, aiding in the prediction of emerging viral threats and the development of targeted interventions to mitigate their impact.
Title : Prophylactic and molecular approaches for mitigating human influenza A viruses: i. Evaluating influenza vaccine effectiveness in the older population ii. Down-regulation of influenza virus genes with novel sirna-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Title : Homology analysis of MPXV and VACV peptides underscores the need to consider both MPXV clades for vaccine development
Lara Isis Teodoro, Mayo Clinic, United States
Title : Development of a novel multi-component vaccine to address the burden of otitis media in high-risk populations
Ayesha Zahid, Griffith University, Australia
Title : High seroprevalence of RSV antibodies in adults indicates potential undetected transmission and requires further public health assessment
Lara Isis Teodoro, Mayo Clinic, United States
Title : The role of immunity in the pathogenesis of SARS-COV-2 and in the protection generated by COVID-19 in different age groups
Ahmed Abdulazeez, BHRUT Trust, United Kingdom
Title : New biomarkers in leishmania major vaccine development
Negar Seyed, Pasteur Institute of Iran, Iran (Islamic Republic of)
Title : Tubercular disease in children: Optimizing treatment strategies through disease insights
Elena Chiappini, University of Florence, Italy
Title : Approaches towards developing and establishing a biomanufacturing research & development, and manufacturing industry in Zimbabwe: A review of the need, potential funding sources, policy development and implementation
Elliot Nyagumbo, Midlands State University, Zimbabwe
Title : Racial disparities in pediatric pneumonia in Brazil: The role of structural racism forging inequalities in acess to vaccines
Livia Daflon Silva, Federal University of State of Rio de Janeiro, Brazil
Title : Capillary electrophoresis for adjuvanted multivalent recombinant vaccine purity determination
Ashley Prout, Merck, United States