Viral core proteins are essential components of a virus's structure, playing crucial roles in the viral life cycle. These proteins are typically located at the core or nucleocapsid of the virus and are involved in packaging and protecting the viral genome. One example is the capsid protein, which forms the protective outer shell of the virus. This protein is responsible for encapsulating and shielding the viral genetic material from the host cell's defenses. The capsid may have various shapes, such as icosahedral or helical, depending on the virus type. Another critical core protein is the nucleocapsid protein, which directly interacts with the viral genome, ensuring its proper condensation and organization. The nucleocapsid protein is crucial for genome replication, transcription, and packaging. In retroviruses like HIV, the core protein, p24, forms the viral capsid, protecting the viral RNA during its journey from the host cell entry to integration into the host genome. Understanding viral core proteins is fundamental for designing antiviral strategies, as disrupting these components can inhibit viral replication and assembly. Research in this area contributes to the development of antiviral drugs and vaccines aimed at targeting the core components of various viruses.
Duccio Medini
BioForge, United States
Jocelyn Jakubik
Apex Pathogen Solutions, United States
Sergey V Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Rosane Cuber Guimaraes
Bio-Manguinhos/ Fiocruz, Brazil
Zhujun Ao
University of Manitoba, Canada
Sergey V Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Ashish Kumar Maurya
John Snow India, India
Sajal Dey
BRIC-Centre for DNA Fingerprinting and Diagnostics, India
Ayman H M El Deeb
Cairo University, EgyptSubmit your abstract Today
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