The tumor microenvironment (TME) poses challenges to vaccine efficacy, as it often creates a suppressive environment that hinders immune responses. The TME comprises various cells, including regulatory T cells and myeloid-derived suppressor cells, which can inhibit the activation and proliferation of immune cells. Vaccine strategies aimed at altering the TME focus on stimulating immune cells within this environment, improving the vaccine's ability to generate an anti-tumor response. Some approaches involve using adjuvants that modulate the TME to enhance vaccine-induced immunity. Additionally, combining vaccines with treatments that target TME components, such as immune checkpoint inhibitors, can improve vaccine responses in cancer therapy. By understanding and overcoming the barriers posed by the TME, researchers hope to enhance the efficacy of cancer vaccines and create more favorable conditions for immune system engagement.
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Title : Tubercular disease in children: Optimizing treatment strategies through disease insights
Elena Chiappini, University of Florence, Italy
Title : Prophylactic and Molecular Approaches for Mitigating Human Influenza A Viruses: i. Evaluating influenza Vaccine Effectiveness in the Older population ii. Down-regulation of influenza virus genes with novel siRNA-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Title : The role of immunity in the pathogenesis of SARS-COV-2 and in the protection generated by COVID-19 in different age groups
Ahmed Abdulazeez, BHRUT Trust, United Kingdom
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Yousfi Tarek, Nationale Research for Biotechnology Research Center, Algeria
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Livia Daflon Silva, Federal University of State of Rio de Janeiro, Brazil
Title : Immunosuppression in COVID-19 Patients and Emerging Fungal Infections: Vaccines, Diagnosis and Strategies to Treat Comorbidities
K R Aneja, Kurukshetra University, India
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Swarandeep Singh, All India Institute of Medical Sciences, India
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