Signal transduction pathways are crucial for the immune system's response to vaccines, as they regulate how immune cells detect and respond to foreign pathogens. When a vaccine is administered, it interacts with immune cells such as dendritic cells or macrophages, triggering these signaling pathways. These pathways, such as the NF-kB pathway or those involving Toll-like receptors (TLRs), help initiate the immune response by activating transcription factors that stimulate the production of cytokines and other immune signaling molecules. By understanding these pathways, vaccine developers can design vaccines that better regulate the immune response, ensuring a more robust defense. Optimizing these pathways can improve vaccine efficacy by increasing the strength of the immune response, enhancing the production of antibodies, and ensuring long-term immunity. Additionally, it allows researchers to develop vaccines that balance immune activation, minimizing adverse effects while maximizing protective immunity against pathogens.
Title : Prophylactic and molecular approaches for mitigating human influenza A viruses: i. Evaluating influenza vaccine effectiveness in the older population ii. Down-regulation of influenza virus genes with novel sirna-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Title : Homology analysis of MPXV and VACV peptides underscores the need to consider both MPXV clades for vaccine development
Lara Isis Teodoro, Mayo Clinic, United States
Title : High seroprevalence of RSV antibodies in adults indicates potential undetected transmission and requires further public health assessment
Lara Isis Teodoro, Mayo Clinic, United States
Title : A promising novel approach to DNA vaccines
Khursheed Anwer, IMUNON, United States
Title : The role of immunity in the pathogenesis of SARS-COV-2 and in the protection generated by COVID-19 in different age groups
Ahmed Abdulazeez, BHRUT Trust, United Kingdom
Title : Development of a novel multi-component vaccine to address the burden of otitis media in high-risk populations
Ayesha Zahid, Griffith University, Australia
Title : Tubercular disease in children: Optimizing treatment strategies through disease insights
Elena Chiappini, University of Florence, Italy
Title : New biomarkers in leishmania major vaccine development
Negar Seyed, Pasteur Institute of Iran, Iran (Islamic Republic of)
Title : Racial disparities in pediatric pneumonia in Brazil: The role of structural racism forging inequalities in acess to vaccines
Livia Daflon Silva, Federal University of State of Rio de Janeiro, Brazil
Title : Approaches towards developing and establishing a biomanufacturing research & development, and manufacturing industry in Zimbabwe: A review of the need, potential funding sources, policy development and implementation
Elliot Nyagumbo, Midlands State University, Zimbabwe