Preclinical models play an essential role in vaccine development, serving as the first step in evaluating a vaccine’s safety and effectiveness before human clinical trials. These models often involve the use of animals, such as mice or primates, to simulate how the vaccine will behave in humans. By studying how the immune system responds to the vaccine in these animals, researchers can assess key factors such as immune activation, potential side effects, and the optimal dosage. The data gathered from preclinical studies provide crucial insights that guide the design of human clinical trials. Advances in immune system modeling and genetic engineering have made preclinical models more accurate and predictive, reducing the chances of failure in later-stage trials. These models are instrumental in identifying promising vaccine candidates for diseases like cancer, HIV, or malaria, and are continually refined to ensure they closely mimic human responses to vaccinations.
Title : Personalized and Precision Medicine (PPM) via biodesign-driven translational applications and upgraded business modeling to secure the human biosafety: The next-step vaccinomics of the future
Sergey V Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Title : The promise of nanotechnology in Personalized & Precision Medicine: Nano-driven precision vaccinomics of the future
Sergey V Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Title : Recombinant BCG vaccine as a potent anti tuberculosis vaccine candidate
Sajal Dey, BRIC-Centre for DNA Fingerprinting and Diagnostics, India
Title : Emerging nanovaccine strategies for enhanced immune targeting and vaccine performance
Aysel Sadayli, V.Y. Axundov Scientific-Research Institute of Medical Prophylaxis, Azerbaijan
Title : Advancing vaccine availability and equity in low-resource settings: Evidence from Awendo Sub-County, Kenya
Millicent Ochieng, Clinton Health Access Initiative, Kenya
Title : Reaching zero-dose children through adaptive immunization strategies in security-compromised areas of Zamfara State, Nigeria
Attahir Abubakar, Ahmadu Bello University, Nigeria
Title : From local pilots to national policy: Key issues and challenges in implementing nationwide HPV vaccination in China
Shenglan Tang, Duke Global Health Institute, United States