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Lentiviruses

Lentiviruses are a subgroup of retroviruses, characterized by their ability to cause a slow and progressive infection. The term "lenti" is derived from the Latin word "lentus," meaning slow, emphasizing the prolonged incubation period of these viruses. Human immunodeficiency virus (HIV), responsible for acquired immunodeficiency syndrome (AIDS), is the most well-known lentivirus. Lentiviruses have a single-stranded RNA genome that is reverse transcribed into DNA upon entering host cells, integrating into the host genome for persistent infection. Lentiviruses exhibit a broad host range, infecting various species, including humans and other mammals. Their ability to infect both dividing and non-dividing cells distinguishes lentiviruses from other retroviruses. Research on lentiviruses has led to significant insights into viral replication, host interactions, and the development of gene therapy vectors. Lentiviral vectors are used in biotechnology and gene therapy applications due to their ability to efficiently deliver genetic material into target cells.

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