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Inactivated Vaccines

Inactivated vaccines, also known as killed vaccines, are a type of vaccine that utilizes viruses or bacteria that have been neutralized or killed to stimulate an immune response without causing disease. These vaccines are produced by rendering the infectious agent nonfunctional through chemical or physical methods. The inactivated agents in the vaccine cannot replicate or cause infection, making them safe for use, particularly in individuals with weakened immune systems. Inactivated vaccines typically require booster doses to maintain immunity over time. Common examples of inactivated vaccines include the polio vaccine, hepatitis A vaccine, and the whole-cell pertussis component in some versions of the DTP (diphtheria, tetanus, and pertussis) vaccine. Influenza vaccines, both injectable and some nasal spray formulations, also utilize inactivated viruses. While inactivated vaccines provide effective protection, they may require adjuvants or additional components to enhance the immune response. Their safety profile and ability to be used in various populations contribute to their widespread use in vaccination programs globally, preventing a range of infectious diseases.

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