Epigenetic factors play a significant role in how the immune system responds to vaccines, influencing gene expression without altering the DNA sequence itself. Environmental factors, age, and individual genetic predispositions can all impact epigenetic modifications that regulate immune responses. In vaccinology, understanding these factors is critical because they can influence how long-lasting or effective a vaccine’s protection will be. For instance, epigenetic changes may affect the function of immune cells, like T-cells or B-cells, which are responsible for creating immune memory. Researchers are exploring how epigenetic modifications can be leveraged to enhance vaccine efficacy, particularly in vulnerable populations, such as the elderly or individuals with chronic conditions. This emerging area of study could lead to more personalized vaccines that can train the immune system more effectively, improving overall vaccine responses across diverse populations and increasing immunity to a variety of pathogens.
Title : Prophylactic and molecular approaches for mitigating human influenza A viruses: i. Evaluating influenza vaccine effectiveness in the older population ii. Down-regulation of influenza virus genes with novel sirna-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Title : Homology analysis of MPXV and VACV peptides underscores the need to consider both MPXV clades for vaccine development
Lara Isis Teodoro, Mayo Clinic, United States
Title : Development of a novel multi-component vaccine to address the burden of otitis media in high-risk populations
Ayesha Zahid, Griffith University, Australia
Title : High seroprevalence of RSV antibodies in adults indicates potential undetected transmission and requires further public health assessment
Lara Isis Teodoro, Mayo Clinic, United States
Title : The role of immunity in the pathogenesis of SARS-COV-2 and in the protection generated by COVID-19 in different age groups
Ahmed Abdulazeez, BHRUT Trust, United Kingdom
Title : New biomarkers in leishmania major vaccine development
Negar Seyed, Pasteur Institute of Iran, Iran (Islamic Republic of)
Title : Tubercular disease in children: Optimizing treatment strategies through disease insights
Elena Chiappini, University of Florence, Italy
Title : Approaches towards developing and establishing a biomanufacturing research & development, and manufacturing industry in Zimbabwe: A review of the need, potential funding sources, policy development and implementation
Elliot Nyagumbo, Midlands State University, Zimbabwe
Title : Racial disparities in pediatric pneumonia in Brazil: The role of structural racism forging inequalities in acess to vaccines
Livia Daflon Silva, Federal University of State of Rio de Janeiro, Brazil
Title : Capillary electrophoresis for adjuvanted multivalent recombinant vaccine purity determination
Ashley Prout, Merck, United States