Pathogens like influenza, HIV, and SARS-CoV-2 are capable of immune escape through mechanisms such as antigenic variation, where they alter their surface proteins to evade immune recognition. This ability to escape immune detection challenges traditional vaccine efficacy, necessitating innovative approaches. Vaccine strategies are now incorporating tactics to counteract immune escape, including the development of broadly neutralizing antibodies and targeting conserved pathogen components that remain stable despite mutations. Scientists are also experimenting with adjuvants and booster strategies to reinforce immune responses against pathogens capable of immune evasion. By understanding and countering these escape mechanisms, researchers can design vaccines that maintain effectiveness even as pathogens evolve, ensuring continued protection against infectious diseases. These strategies are essential for addressing persistent health threats, as they provide adaptable defenses against pathogens prone to mutation.
Title : Prophylactic and molecular approaches for mitigating human influenza A viruses: i. Evaluating influenza vaccine effectiveness in the older population ii. Down-regulation of influenza virus genes with novel sirna-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Title : Homology analysis of MPXV and VACV peptides underscores the need to consider both MPXV clades for vaccine development
Lara Isis Teodoro, Mayo Clinic, United States
Title : High seroprevalence of RSV antibodies in adults indicates potential undetected transmission and requires further public health assessment
Lara Isis Teodoro, Mayo Clinic, United States
Title : A promising novel approach to DNA vaccines
Khursheed Anwer, IMUNON, United States
Title : The role of immunity in the pathogenesis of SARS-COV-2 and in the protection generated by COVID-19 in different age groups
Ahmed Abdulazeez, BHRUT Trust, United Kingdom
Title : Development of a novel multi-component vaccine to address the burden of otitis media in high-risk populations
Ayesha Zahid, Griffith University, Australia
Title : Tubercular disease in children: Optimizing treatment strategies through disease insights
Elena Chiappini, University of Florence, Italy
Title : New biomarkers in leishmania major vaccine development
Negar Seyed, Pasteur Institute of Iran, Iran (Islamic Republic of)
Title : Racial disparities in pediatric pneumonia in Brazil: The role of structural racism forging inequalities in acess to vaccines
Livia Daflon Silva, Federal University of State of Rio de Janeiro, Brazil
Title : Approaches towards developing and establishing a biomanufacturing research & development, and manufacturing industry in Zimbabwe: A review of the need, potential funding sources, policy development and implementation
Elliot Nyagumbo, Midlands State University, Zimbabwe