Mycobacterium tuberculosis is one of the most dangerous pathogens. Bacterial resistance to antituberculosis drugs grows each year, but searching for new drugs is a long process. Testing for available drugs to find active against mycobacteria may be a good alternative. In the [....] » Read More
Rheumatoid arthritis (RA) is one of the most common chronic inflammatory autoimmune disease. Patients with RA have a significant increased risk of serious infection following treatment with disease- modifying antirheumatic drugs, and &nbs [....] » Read More
Immunoinformatics plays a key role in vaccine design and antibody production. In the past, antibody design and vaccine development are expensive and time-consuming. Nowadays, advances in the field of bioinformatics have provided practical tools that can be used to lessen the time [....] » Read More
Major hindrances to getting a COVID-19 vaccine include vaccine hesitancy, skepticism, refusal, and anti-vaccine movements. Several studies have been conducted on attitudes of the public towards COVID-19 vaccines and the potential influencing factors. The purpose of this scoping r [....] » Read More
Background – Since the day the Novel SARS Cov has been detected and the ensuing pandemic the search for a cure or prevention has been the only target of the medical fraternity. As the second wave racked havoc Vaccine seemed the only viable option to stop this global su [....] » Read More
Brucellosis is a zoonotic bacterial infection of pandemic potential – caused by Brucella species. Lack of vaccines against human brucellosis despite continuous research has led us to address this issue using several selectively chosen antigens pertaining to B [....] » Read More
This fact is well known that the appearance and development of all fish disease process could be the result of the interaction between three parameters such as pathogen, host, and environment. Therefore, only multidisciplinary studies involving knowledge of the characteristics of [....] » Read More
The physicians are talking about the treatment of fever indifferently. They are talking about not to treat fever but for the underlying cause of fever. At the same time when people have a fever, they instruct to reduce fever urgently. The cause of fever and cause of disease [....] » Read More
To generate more effective subunit vaccines against complex organisms like Leishmania parasites, we need to fuse several immunogenic proteins together. However, the critical issue is that which arrangement of the constituting components should be selected as the favored [....] » Read More
Japanese encephalitis (JE) is a vector-borne zoonotic viral disease caused by (Japanese encephalitis virus, JEV). Vaccination is the most effective way to control JE in both humans and pigs. However, JEV genotype shift that the dominant genotype III (GIII) has been replaced by ge [....] » Read More
During recent years we have witnessed numerous occurrences of viral infectious diseases such as Ebola, MERS, SARS, and recently COVID-19 with a drastic negative effect on human health. Following the outbreak of the COVID-19 pandemic, it has been declared a public health emergency [....] » Read More
All treatments for fever are based on the belief that fits is the result of 41 degrees Celsius temperature and it damages cells of the brain and body. At the same time, there is no evidence-based tests or concrete diagnosing methods to the belief that fits and brain damage i [....] » Read More
First of all I would like to discuss about the global pandemic covid 19 outbreak across the Whole World & how much impact on human after spreading this virus globally.Most of the peoples has been said its (virus) originated from china ,Wuhan state.whatever this virus was incr [....] » Read More
Background: Vaccine coverage is lower for influenza than for other vaccines, varying by age, race/ethnicity, and region. Vaccine safety concerns are common despite a lack of epidemiological evidence. We characterized vaccine hesitancy and identified associations with influen [....] » Read More
Title : Characterising the dendritic cell response to BCG using a bovine afferent lymphatic cannulation model and Single Cell RNA Seq
Heather Mathie, Roslin Institute, University of Edinburgh, United Kingdom
Vaccination is a key component in the control of animal pathogens that impact the livestock industry. However, deployable, efficacious vaccines remain unavailable for many prevalent diseases, particularly those requiring cell-mediated immunity, such as bovine tuberculosis (TB). I [....] » Read More
Title : Bovine leukemia virus tax gene/tax protein and premiRNA genes polymorphism and its relation to Enzootic Bovine Leukosis
Irina Zyrianova, Institute for Innovative Biotechnologies in Animal Husbandry, Russian Federation
The aim of this study is the investigation of the polymorphism of the tax gene/Tax protein and pre-miRs-B (pre-miRNA genes of Bovine leukemia virus (BLV)) polymorphism and its relation to Enzootic Bovine Leukosis. Methods: Peripheral blood samples of 2 to 5 years old female Ho [....] » Read More
Title : Identification of Hobi like pestivirus as a contaminant of the vaccine against peste des petits ruminants
Afshona Anoyatbekova, Federal Scientific Centre, Russian Federation
Introduction and objective: Along with the success of developing biological products of new generation the traditional vaccines, as well as hyperimmune sera, remain as the main means of preventing viral diseases in animals. However, there is a potential threat of the dissemi [....] » Read More
Title : Immunogenicity of DNA Vaccines based on Multicistronic Vectors and Synthetic DNA Delivery Systems
Khursheed Anwer, IMUNON, Inc., United States
Nucleic acid-based vaccines represent an attractive alternative to live attenuated and subunit-based vaccines due to their capacity to trigger both humoral and cellular immunity and potential for low-cost and shortened production processes. The fast-track approval and the worldwi [....] » Read More
Title : Fluorescence A-TEEM Method for Vaccines Characterization
Alessia Quatela, HORIBA Scientific, France
We will present several examples to highlight the capabilities of the fluorescence A-TEEM method, a novel approach which combines UV/Vis with fluorescence EEM spectroscopy. The benefit of this approach is the ability to provide robust and rapid spectroscopic characterization of v [....] » Read More
Title : Is The Mandatory Implementation of a Passport for COVID 19 Vaccine Reduce the Transmission or Not
Huang Wei Ling, Medical Acupuncture And Pain Management Clinic, Brazil
In this theme the author will discuss various explanations that was used or not to implement this kind of rules in Europe and in many countries nowadays. Purpose; to demonstrate that using only this type of measures to control the spread of the virus, will not be reducinf [....] » Read More
Title : Why Do Patients Still Have Potential to Transmit Covid 19 Despite Receiving Vaccination
Huang Wei L, Medical Acupuncture and Pain Management Clinic, Brazil
This process is not very easy to explain in the eyes of Western medicine and the author will explain it from the perspective of traditional Chinese medicine, following the commandments of Hippocrates, father of medicine. In an article written by the author entitled Is SARS-C [....] » Read More
Title : Vaccine against S. pyogenes
Luiza Guilherme, University of Sao Paulo, Brazil
StreptInCor, a candidate vaccine against S. pyogenes is based on protective 55 amino acids residues of C-terminal portion of the M protein. Experimental assays have demonstrated that the StreptInCor peptide induces high titers of opsonic and neutralizing and prote [....] » Read More
Title : COVID 19 vaccines contraindications
Alibek Adil, Kazakh-Russian Medical University, Kazakhstan
There is no doubt that vaccines are the most effective solution against the global challenges that pandemic brought to the world. In addition, thousands of studies all around the web are publishing the succeed results and social media is spreading them rapidly. Nevertheless, ther [....] » Read More
Title : INO 4500, a DNA based LASV vaccine, induces robust T cell responses and long-term memory antigen-specific T cells
Idania Marrero, Inovio Pharmaceuticals Inc, United States
Lassa fever (LF) is an acute viral haemorrhagic disease caused by Lassa virus (LASV), which is endemic in Western Africa and is associated with high rates of infection and mortality. Currently, there are limited treatment options and no licensed vaccines to protect against LASV i [....] » Read More
Title : Nature inspired nanoparticle based DNA vaccine
Hao Song, The University of Queensland, Australia
Recent advances in nanotechnology has greatly boosted the development of drug delivery systems for therapeutic and vaccine applications, in particular the great success in nanoparticle-based mRNA vaccines for COVID-19. To be noted, rational design and fabrication of safe and effi [....] » Read More
Title : Production and biological characterization of egg yolk antibodies (IgY) against Ftr1 iron permease of Candida albicans
Patricia Canteri de Souza, State University of Londrina, Brazil
Iron is essential for the functionality of biological processes, however, excess iron is toxic. In humans, due to its toxicity, this metal is found coupled to proteins, such as transferrin, which transports iron to tissues, and ferritin, an intracellular storage molecule of this [....] » Read More
Title : Development of universal influenza vaccine using M2e conjugated PLGA nanoparticle
Gaurav Joshi, Texas Tech University, United States
To prevent next flu pandemics and to reduce the burden of seasonal flu infections, there is an urgent need to develop vaccines that are broadly protective against different influenza strains. In this regard we investigated polymeric nanoparticles as antigen carriers of a highly c [....] » Read More
Title : Focus on vaccine safety: the clinical relevance to keep focusing on the close monitoring and safety surveillance of Covid-19 available and forthcoming vaccines. Can all the available and future safety clinical data be conveyed in one global safety database
Domenico Merante, Global Clinical Development, Switzerland
History teaches us all about the course of past pandemics and the importance of the use of effective and safe vaccines to contribute to prevent diffuse bacterial and viral infections. But vaccines have also generated ethical controversies over the years. It is important to learn [....] » Read More
Title : Endosomal TLRs may have no important effect on higher transmissibility of SARS CoV 2 alpha and delta variants
Azadeh Zahmatkesh, Razi Vaccine and Serum Research Institute, Iran (Islamic Republic of)
Toll-like receptors (TLRs) are essential for activation of innate immunity and initiation of adaptive immune response. They have been associated with several respiratory diseases, but information on the relation of TLRs with SARS-CoV-2 still needs to be completed. Endosomal TLRs [....] » Read More