It’s not just the bacteria or viruses that most commonly cause life-threatening disease in human, some of them could be fungal pathogens. Since 2013, the Leading International Fungal Education (LIFE) portal has facilitated the estimation of the burden of serious fungal infe [....] » Read More
This presentation describes the development of PLACCINE a novel DNA vaccine platform well-suited to overcome the limitations of the current vaccines. The PLACCINE platform leverages the inherent DNA advantages including design flexibility incorporating multi-antigen payload [....] » Read More
Background: Vaccine coverage is lower for influenza than for other vaccines, varying by age, race/ethnicity, and region. Vaccine safety concerns are common despite a lack of epidemiological evidence. We characterized vaccine hesitancy and identified associations with influenza va [....] » Read More
Immune senescence and inflammaging render older persons more susceptible to severe consequences of infectious diseases and likely to exhibit poorer responses to vaccination. Older persons need influenza, pneumococcal, herpes zoster, pertussis and SARS-CoV-2 vaccines and soo [....] » Read More
The production, extraction, and use of antibodies from birds is an innovative methodology that supports several purposes, from passive immunotherapy to prophylaxis and diagnosis of diseases. Immunoglobulins Y (IgY), produced by chickens, are functionally similar to immunoglobulin [....] » Read More
Medical textbooks say that modern science does not know enough about fever and there is no uniform definition. Physicians do not know the purpose of fever. Because fever is believed to be dangerous to the body, modern science has not looked at what our bodies have done wi [....] » Read More
Making proven intervention available to the host community is increasingly becoming a moral obligation than a researcher’s discretion. This study aimed to explore whether host communities of HIV vaccine trials ought to access the vaccines at no or subsidized princes. A case [....] » Read More
Vaxsia has developed a self-assembled protein nanoparticle (PNP) platform, VADEX. The building block of VADEX is a fusion protein contains two functional modules: polymerization module and antigen presentation module. The polymerization module is modified from an amphipathic heli [....] » Read More
Today, with the development of technology and the expansion of genomics, the vaccine design process has been transferred from laboratory and practical research to the workroom and designs based on bioinformatics and genomic studies. This change has reduced costs and eliminated ex [....] » Read More
In this lecture, I want to talk about the role of vaccine in critically ill adult patients in ICU – How different vaccines are directly or indirectly help in reducing disease severity and morbidity of certain disease which are otherwise associated with high morbidity and mo [....] » Read More
The scourge of tuberculosis and other intracellular infection is continuing to toll millions of human lives annually. Unfortunately, in the present scenario we are not having effective vaccines against most of the intracellular infections. For example, the only vaccine against tu [....] » Read More
The UK Health Security Agency (UKHSA) has longstanding expertise in the technological support of vaccine development through a vast array of immunological assays. In early 2020, using this valuable knowledge, scientists within UKHSA were able to rapidly develop a live virus micro [....] » Read More
In our interconnected modern world, diseases like covid-19 threaten global security and global development. More must be done to generate the political will to secure adequate, sustainable investment in vaccines and ensure equitable access around the world. The Immunisation Re [....] » Read More
Background: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attenuates and antibodies from the coronavirus disease 2019 (COVID-19) vaccine decline, long-term attention should be paid to the durability of primary-booster administration and the preventive effect [....] » Read More
Neonatal sepsis is a bloodstream infection that affects newborn infants under the age of 28 days and is a leading cause of morbidity and mortality in these children 1,2. There is little information on the prevalence of newborn sepsis, however Fleischmann-Struzek et al. estim [....] » Read More
S. pneumoniae ranks as the fourth most lethal pathogen globally in terms of fatalities associated with or attributable to resistance. ATLAS surveillance study from India aims to study the overall antimicrobial susceptibility (AMS) among pneumococcal isolates collected between 201 [....] » Read More
Complete childhood vaccination remains poor in Sub-Saharan African countries. Although missed opportunity for vaccination (MOV) was found responsible for low coverage, median time-to-corrected is useful to assess delay in vaccination. MOV also reflects quality of immunization ser [....] » Read More
The development of efficient vaccine delivery systems is critical to enhance immunization strategies and combat a wide array of infectious diseases. Mucosal vaccines have emerged as a promising approach, leveraging the body's natural immune response at the site of pathogen en [....] » Read More
Rationale: Drug-associated adverse effects are one of the most important entities in clinical medicine. Involuntary movements may have a dynamic serious impact on myocardial muscle. Myoclonus is well abnormal involuntary movements with a distinct description. Myoclonus is a physi [....] » Read More
This study aimed to systematically review the facilitators and barriers influencingHPVvaccineaccessibility among women in China. The analysis is based on a synthesis of 24 relevant studies,focusing on key factors such as geographic disparities, knowledge gaps, populationdemograph [....] » Read More
Infectious diseases continue to pose a significant threat to global public health, highlighting the critical need for effective prevention strategies. Vaccination has long been recognized as one of the most successful and cost-effective interventions in the fight against infectio [....] » Read More
In December 2019, the coronavirus disease 2019 (COVID-19) first became identified in the market places of Wuhan, China. The first incidence of COVID-19 was identified in Saudi Arabia on March 2, 2020, and then within a month, the total number of reported instances had risen to ov [....] » Read More
During the current era of the COVID-19 pandemic, the dissemination of Mucorales has been reported globally, with elevated rates of infection in India, and because of the high rate of mortality and morbidity, designing an effective vaccine against mucormycosis is a major health pr [....] » Read More
The hepatitis B virus infection remains a major public health problem worldwide. It can lead to a liver cirrhosis and/or hepatocellular carcinoma. The World Health Organization (WHO) has recommended the implementation of generalized vaccination programs against hepatitis B. In Ca [....] » Read More
Introduction In recent years, politics and business have become increasingly intertwined, with employees increasingly seeking workplaces that align with their political views (Stuckatz, 2020). The COVID-19 pandemic response introduced public health regulations that became cont [....] » Read More
The use of low-energy electron irradiation (LEEI) is a novel and highly efficient method for manufacturing vaccines and other pharmaceutical products. This technology provides advantages against conventional methods for virus inactivation, as the process is faster, does not requi [....] » Read More
Gonorrhea is an urgent antimicrobial resistance threat and its therapeutic options are continuously getting restricted. Moreover, no vaccine has been approved against it so far. Hence, the present study aimed to introduce novel immunogenic and drug targets against antibiotic-resi [....] » Read More
Viral fusion proteins enable cellular infection by fusing viral and cellular membranes accompanied by their transition from the pre-fusion to the post-fusion conformation during viral entry. Fusion proteins in their prefusion conformation elicit high neutralizing antibodies [....] » Read More
Viral fusion proteins enable cellular infection by fusing viral and cellular membranes accompanied by their transition from the pre-fusion to the post-fusion conformation during viral entry. Fusion proteins in their prefusion conformation elicit high neutralizing antibodies [....] » Read More
Recent advances in genomic and bioinformatic technologies have enabled the emergence of the field of immunogenomics. This intersection of immunology and genetics has expanded our understanding of how the immune system responds to infection and vaccination. While the immunogenetic [....] » Read More
Title : Vaccines and monoclonal antibodies in the prolonged treatment of non-small cell lung cancer: 20 years of follow-up
Mayra Ramos Suzarte, Center of Molecular Immunology, Cuba
Lung cancer is the first cause of death from cancer in the world and in some countries as the first cause of death for both sexes. Early diagnosis and timely therapy is successful for increasing the survival of these patients, however, the masking with frequent symptoms of other [....] » Read More
Title : Observational study post emergency use authorization of itolizumab in the treatment of COVID-19
Mayra Ramos Suzarte, Center of Molecular Immunology, Cuba
COVID-19 continues to be a global health problem, it is a multifactorial disease characterized by a process of hyperinflammation. Itolizumab, a humanized anti-CD6 mAb, has the Emergency Use Authorization (UEA) for patients with this disease with signs of hyperinflammation. Method [....] » Read More
Title : Vaccine for AML: 2023 and beyond
Stefan Gluck, Vice President, Global Medical Affairs at Celgene Corporation, United States
The idea of using the immune system to fight cancer is over 100 years old. (Paul Ehrlich’s “Magic Bullet”). New cellular and molecular approaches over the last 2 decades or so, led to a better understanding of the immune system. Our focus became the T cell, its [....] » Read More
Title : Purification process development of COVID antigens to identify sera needed for plasma therapy
Sushmita Koley, Senior Scientist Bio-Rad Laboratories, United States
One of the crucial steps in deploying plasma therapy for COVID-19 has been the development of critical assays to detect SARS-CoV-2 antibodies and evaluate their potential suitability. Unfortunately, assays that assess neutralizing antibodies involve use of live SARS-CoV-2 virus i [....] » Read More
Title : Lessons that can be learned from the rollout of the COVID-19 vaccine and the acceptance of vaccination from healthcare professionals, frontline workers and patients that need to be considered in developing a vaccine
Regina Au, BioMarketing Insight, United States
When the COVID-19 Vaccine was developed, time was crucial and the pharmaceutical and biotechnology companies primary goal was to get a vaccine out as soon as possible so people to get vaccinated in saving lives. What wasn't considered which most large companies co [....] » Read More
Title : Lessons learned for the future of social listening to address vaccine misinformation
Joe Smyser, The Public Good Projects, United States
Introduction: As the pandemic evolves and nations refocus on routine immunizations and vaccine-preventable outbreaks, it is critical to continue increasing vaccine demand. Misinformation threatens the success of vaccination programs across the world. Since 2017, The Public Good P [....] » Read More
Title : Why Low-Energy-Electron Irradiation might be a potential game changer for vaccine development, manufacturing, and pandemics prevention
Daniel Becker, KyooBe Tech GmbH, Germany
In the ongoing global Covid-19 aftermath, epidemics and pandemics triggered by microbial and viral pathogens remain a significant challenge for global vaccine production and worldwide supply. The Irradiation of target pathogens with low-energy electrons (LEEI) can reliably and [....] » Read More
Title : National immunization management system- NIMS
Kashif Zulfiqar, Project Manager - NADRA, Pakistan
National Immunization Management System (NIMS) in Pakistan envisages to consolidate all immunization activities that are being carried out in the country, on a single intelligent platform including vaccination scheduling, vaccine administration, role based reporting, complaint [....] » Read More
Title : Medicinal synthetic aluminum-magnesium silicate {Al4 (SiO4)3 + 3Mg2SiO4?2Al2 Mg3 (SiO4)3} effective for: Viral diseases; Tumors; Antimicrobial resistant infections
Maduike Chiehiura Onwubiko Ezeibe, Michael Okpara University of Agriculture, Nigeria
Viral diseases, cancers (tumors) and antimicrobial resistant infections are among the world`s biggest health challenges. Literature reveals, that HIV and COVID-19 virus (RNA viruses) are positively charged while DNA viruses and abnormal (tumor/infected) cells are negatively charg [....] » Read More
Title : Moving the needle for covid-19 vaccinations in Nigeria through leadership, accountability, and transparency
Fejiro Chinye Nwoko, Nigeria Solidarity Support Fund, Nigeria
Background: The first set of vaccines arrived in Nigeria in March 2021. The National Primary Health Care Development Agency (NPHCDA) set out to vaccinate at least 70% percent of Nigeria’s eligible population i.e., 111,776,503 people, by December 2022. As of June 2021, only [....] » Read More
Title : Measles immunization research western lake state, South Sudan
Nebiyu Lera Alaro, Medecins Sans Frontieres, Ethiopia
Most global estimates indicate that more than 1 million children a year die from acute measles. The actual number of deaths may, however, be considerably higher than this. In addition, the impact of delayed mortality as a result of measles infection is only now being realized. Ma [....] » Read More
Title : Assessment of health workers knowledge and practiceson vaccines storage and cold chain management in the Techiman Municipality.
Carless Gyamfuaa Ameyaw, Holy Family Hospital, Ghana
Background: The contribution of immunization to humanity is invaluable, especially to children. This makes assessment of the vaccine cold chain system of any immunization programme crucial to determine its strengths and weaknesses at all levels. The World Health Organization and [....] » Read More
Title : Reactive arthritis following mpox monkey pox vaccination
Indira Acharya, Medstar, United States
however ANA, rheumatoid factor Reactive arthritis after various vaccinations has been previously described but such kind of reaction after mpox vaccination has not been previously reported. Here we present a case of recently diagnosed reactive arthritis following intradermal mpox [....] » Read More
Title : Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques
Malika Aid, Harvard School of Medicine, United States
Syrian golden hamsters exhibit features of severe disease after SARS-CoV-2 WA1/2020 challenge and are therefore useful models of COVID-19 pathogenesis and prevention with vaccines. Recent studies have shown that SARS-CoV-2 infection stimulates type I interferon, myeloid, and infl [....] » Read More
Title : Burden of antibiotic resistance at wolaita sodo university comprehensive specialized hospital, ethiopia
Temesgen Anjulo Ageru, Wolaita Sodo University Comprehensive Specialized Hospital, Ethiopia
Background: Antibiotic resistance is a serious threat to the human population everywhere. However, less attention is given to its concern in sub-Saharan Africa including Ethiopia. There is an information gap concerning antibiotic resistance and its pattern in Wolaita Sodo Univers [....] » Read More
Title : Probiotics potential for the prevention and treatment of transmissible coronavirus COVID-19
Shoukat Parvez, The University of Faisalabad, Pakistan
COVID-19 is pandemic disease which is caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2SARS-CoV-2 was first identified in China in 20119, and subsequently spread world over. The lack of a vaccine or curative treatment for COVID-19 necessi [....] » Read More
Title : Willingness to accept COVID-19 vaccine and its determinants in ethiopia: A systematic review and meta-analysis
Getahun Fetensa, School of Nursing and Midwifery, Ethiopia
Introduction: Vaccination is one of the most crucial strategies in the control of pandemics such as COVID-19. Although a couple of research has been conducted to assess the willingness of the population to accept the COVID-19 vaccine, the findings are inconsistent and inconclusiv [....] » Read More
Title : Immunoglobulin G IgG specific responses to recombinant Qβ displayed MSP3 and UB05 in plasma of asymptomatic plasmodium falciparum infected children living in two different agro-ecological settings of Cameroon.
Ouambo Fotso Herve, Centre International De Reference Chantal Biya, Cameroon
Introduction: In areas with intense perennial malaria transmission, limited data is available on the impact of environmental conditions especially rainfall on antibody responses against malaria vaccine candidates. For this reason, we have compared IgG antibody responses specific [....] » Read More
Title : To create awareness & address misconception regarding vaccine and immunization process, by highlighting the role of vaccine in the development of immune in human.
Kaleem Ullah Khan, Polio Eradication and routine immunization program, Pakistan
Vaccine hesitancy: we do have a lot of issues from the community which make them hesitant towards vaccination process, includes disinformation about the vaccination spread by the community instigators play important role in this regards apart from that we do have a lot of religio [....] » Read More
Title : Long term survival of patients with anaplastic cancer in resource limited setting: A case report
Dereje Gashaw Andargie, Bahirdar University, Ethiopia
Anaplastic thyroid cancer is a very aggressive tumor that advances quickly. Women and seniors are the most affected. After diagnosis, the median survival time is no longer than 6 to 8 months. Case presentation A 60-year-old female patient from the northwest of Ethiopia was ad [....] » Read More
Title : System serology approach on COVID-19 patients’ sera reveal specific immune pattern in the heterogeneous population: The COVIDAuRA study
Levast Benoit , BIOASTER, France
The emergence of multiple SARS-CoV-2 variants as well as the implementation of different vaccination strategies gave rise to multiple immunization schemes in the population and related questions: which immunization strategy leads to the most effective long-term immune response ag [....] » Read More
Title : Nirmatrelvir-Ritonavir Counseling and Acceptance in Pregnancy
Kristen Lee Moriarty, UCONN Health, United States
The National Institute of Health recommends Nirmatrelvir-Ritonavir (NIR) treatment for pregnant patients with COVID-19. However, little is known about NIR treatment acceptance rates in pregnant patients and what strategies may increase access and acceptance rates of NIR treatment [....] » Read More
Title : management of arterial hypertension and diabetes in elderly people as well as COVID-19 prevention
Nzolameso makaya Jennifer, Hopital General De Reference De Kimbanseke Pierre Pokom, Congo
70% of people over 65 are hypertensive; high blood pressure increases the risk of exposure to cardiovascular disease (myocardial infarction and heart failure) and stroke. This is a public health problem, given the aging of the population. There are few studies carried out in e [....] » Read More
Title : The impact of COVID-19 on HPV vaccination: "Examining the role of stakeholders in sustaining demand and equity post-pandemic.
Vincent Omondi, Clinton Health Access Initiative, Kenya
The COVID-19 pandemic has had a significant impact on global healthcare services, including routine immunization programs. In particular, the pandemic has disrupted human papillomavirus (HPV) vaccination efforts, which are critical in preventing HPV-related cancers. This review e [....] » Read More
Title : Defense mechanisms against MERS-CoV infection and immunological memory in human mucosal tissues for designing intranasal vaccines candidates.
Khalid Jebril Shrwani, Public Health Authority, Saudi Arabia
Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a deadly pathogen with a mortality rate of up to 34.4% that can cause severe respiratory tract disease and multiorgan failure. Therefore, there is a pressing need for both successful antiviral vaccines and eff [....] » Read More
Title : Restoring confidence in routine immunization during Covid-19 pandemic in Bangladesh
Tanvir Hossen, Expanded Program on Immunization (EPI), Bangladesh
For several years, outreach immunization sessions in Bangladesh were hosted in the homes of individuals. Vaccinators called Health Assistants would sit in the living rooms or house yards of local community members, including mullahs and other leaders, while caregivers would gathe [....] » Read More
Title : In depth analysis of reason of Zero dose among children in urban slum of Nepalgunj: A qualitative study
Tripti Pal Raman, World Health Organization, Nepal
In Nepal significant increase of zero dose children from1% to 4% have alerted all the stakeholders associated with child immunization1 . In addition to this increasing outbreak of vaccine preventable diseases in the areas with low vaccination dose are showing importance of increa [....] » Read More
Title : The Evaluation of bacterial pollution of external surface of cockroaches collected from several hospitals of Hamadan Iran
Mansour Nazari, Hamadan University of Medical Sciences, Iran (Islamic Republic of)
Objectives: The cockroaches are the most important Transmitter of Pathogenic pathogens. The presence of cockroaches as insects that are free to move outside and inside hospitals can lead to pathogenic bacteria, which are considered as one of the problems of health devices a [....] » Read More
Title : A cross sectional study to evaluate people knowledge, attitude and practice towards using disinfectants and sanitizers during covid 19 pandemic in bangladesh
Ismail, Globe Biotech ltd,Bangladesh, Bangladesh
The devastating novel coronavirus (COVID-19) pandemic worldwide has become a global health crisisThis disease is highly contagious and caused by the transmission of severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2). To prevent the transmission of SARS-CoV-2, disinfect [....] » Read More
Title : Association between COVID-19 vaccination and menstrual disturbances: A retrospective cohort analysis.
Lev Ramirez, Universidad de La Sabana , Colombia
In the wake of the COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), the global healthcare landscape has undergone a profound transformation. This transformation has been marked by the rapid development and deployment of COVID-19 vaccines [....] » Read More
Title : Single cell profiling of B cell and T cell after SARS-CoV-2 mRNA vaccination
Hye Jin Kim, Division of Clinical Vaccine Research, Korea, Republic of
B cells and T cells are known to play important roles during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and vaccination. To understand changes in immune response to SARS-CoV-2 vaccination, changes in single cell RNA sequencing were conducted in serial [....] » Read More