Diabetes is a metabolic chronic disease characterized by elevated blood glucose levels over a prolonged period which occurs either when the pancreas does not produce enough insulin or the human’s body cannot effectively use the insulin it produces. Worldwide, 590 million pe [....] » Read More
Influenza viruses are known to cause respiratory illnesses that often lead to mortality and morbidity in humans worldwide. Currently available vaccines, predominantly target highly variable surface glycoproteins, thereby reducing the protective efficacy of vaccine overtime due to [....] » Read More
The rapid evolution of vaccine science has accelerated interest in nanotechnology-based strategies aimed at improving immune precision, vaccine stability, and translational performance. Nanovaccines have emerged as versatile platforms capable of addressing critical limitations of [....] » Read More
Reaching zero-dose children remains a major challenge to routine immunization in northern Nigeria, particularly in security-compromised settings. Zamfara State has experienced prolonged armed banditry, population displacement, and repeated disruption of basic services, all of whi [....] » Read More
Rabies remains a zoonotic public health problem in Ghana despite the availability of effective preventive measures, including mass dog vaccination and timely post-exposure prophylaxis (PEP). We conducted a community-based cross-sectional mixed-methods study between June and Decem [....] » Read More
The rapid development of COVID-19 vaccines marked an unprecedented scientific achievement. However, translating vaccine candidates from preclinical stages to successful clinical implementation posed significant challenges, particularly in developing countries. These challenges sp [....] » Read More
Tropical areas like Bangladesh are endemic for the tick-borne hemoprotozoan diseases babesiosis, anaplasmosis, and theileriosis (BAT). They infect erythrocytes, resulting in output decreases, illness, and mortality that are predicted to cost the world economy more than US$24 bill [....] » Read More
Novavax’s Matrix-M®–adjuvanted protein nanoparticle SARS-CoV-2 vaccine has demonstrated robust immunogenicity and acceptable safety in adult and pediatric populations worldwide and among immunocompromised individuals. The original vaccine targeting the ancestral s [....] » Read More
Title : A universal AI design framework and brokerage platform for democratised manufacturing of mRNA therapeutics
Duccio Medini, BioForge, United States
The growth of mRNA as a general platform for biologics is limited by bespoke manufacturing processes that require adaptation across products and scales. To overcome this barrier to access and innovation, we developed an AI-driven framework that decouples sequence design from m [....] » Read More
Title : Personalized and Precision Medicine (PPM) via biodesign-driven translational applications and upgraded business modeling to secure the human biosafety: The next-step vaccinomics of the future
Sergey V Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the subclin [....] » Read More
Title : Development of VSV-vector based vaccine against H5N1 avian influenza by targeting both H5N1 hemagglutinin and matrix protein 2
Zhujun Ao, University of Manitoba, Canada
Human (avian) influenza A viruses, especially highly pathogenic avian influenza (HPAI) viruses, pose a significant public health threat, and a multivalent vaccine is the primary prophylactic measure to control these viruses. To this goal, we generated two vesicular stomatitis vir [....] » Read More
Title : A novel responsive microneedle platform for reliable drug and vaccine delivery
Huanhuan Li, Queen’s University Belfast, United Kingdom
Introduction: Driven by rising demand for minimally invasive healthcare, ageing populations and at-home treatment options, microneedles (MNs) offer a compelling alternative to injections, particularly for vaccines and chronic therapies. However, commercial adoption has been [....] » Read More
Title : The promise of nanotechnology in Personalized & Precision Medicine: Nano-driven precision vaccinomics of the future
Sergey V Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Biodesigners, biotechnologists and biomanufacturers are beginning to realize the promise of Personalized and Precision Medicine (PPM), translating to direct benefit to patients or persons-at-risk. Both PPM, personalized vaccinomics and nanobiotechnologies are being integrated in [....] » Read More
Title : Comparative efficacy of different H9N2 avian influenza virus inactivated vaccines using some commercially available adjuvants for superior control in broilers
Ayman H M El Deeb, Cairo University, Egypt
Avian influenza viruses are widely spread worldwide and continue to cause sever economic losses in many countries. The endemic countries including Egypt use different strategies to control the disease including vaccination. There are 3 different AIV serotypes circulating in Egypt [....] » Read More
Title : Structure-based design and development of next-generation Respiratory Syncytial Virus (RSV) vaccine
Lei Chen, Yikang Biotech Suzhou Co., Ltd, China
Respiratory syncy????al virus (RSV) and human metapneumovirus (hMPV) are prevalent respiratory pathogen that primarily affect infants, young children, older adults, and individuals with compromised immune systems. Current RSV subunit vaccines are based on a fusion protein that is [....] » Read More
Title : Unmasking urban immunization inequities: A cross-sectional LQAS analysis of zero-dose drivers in slum and non-slum settings of Uttar Pradesh, India
Ashish Kumar Maurya, John Snow India, India
Background: Despite steady gains in routine immunization, substantial intra-urban inequities persist in Uttar Pradesh, particularly within informal settlements. Urban slums represent complex ecosystems where social vulnerability, mobility, and service delivery constraints converg [....] » Read More
Title : Advancing vaccine availability and equity in low-resource settings: Evidence from Awendo Sub-County, Kenya
Millicent Ochieng, Clinton Health Access Initiative, Kenya
Background: Despite national progress in Kenya’s Expanded Program on Immunization (KEPI), vaccine availability and equitable access remain uneven across sub-counties. Awendo Sub-county in Migori County continues to face challenges related to inconsistent vaccine supply [....] » Read More
Title : Responding to mpox in Africa: Vaccine strategy during sustained human transmission
Charles Ugochukwu Ibeneme, Africa Centers for Disease Control and Prevention(Africa CDC), Ethiopia
Background: The 2024 resurgence of mpox driven by Clade Ib prompted declarations of a Public Health Emergency of Continental Security and a Public Health Emergency of International Concern. Unlike prior outbreaks, vaccines were mobilized within weeks. We describe progress, o [....] » Read More
Title : From local pilots to national policy: Key issues and challenges in implementing nationwide HPV vaccination in China
Shenglan Tang, Duke Global Health Institute, United States
In October 2025, China announced the inclusion of human papillomavirus (HPV) vaccination into the National Immunization Program (NIP), marking the first addition of a new vaccine to the national schedule since 2008 and the first to explicitly target adolescents rather than young [....] » Read More
Title : Understanding SARS-CoV-2 vaccine hesitancy among pregnant women in Soweto, South Africa: A qualitative study
Zwile Zungu, University of Cape Town, South Africa
Introduction/Background: SARS-CoV-2 vaccine hesitancy among pregnant women in Soweto poses a significant public health concern, especially given the increased risk of COVID-19-related complications during pregnancy. Despite the availability of vaccines, uptake remains low across [....] » Read More
Title : Saudi FDA guideline for chemistry, manufacturing, and control requirements of vaccines
Naser Aldosri, Saudi Food and Drug Authority, Saudi Arabia
Guideline for Chemistry, Manufacturing, and Control Requirements of Vaccines provides an overview of the regulatory, quality, and scientific requirements for the registration of vaccines. It describes expectations related to vaccine characterization, manufacturing, control, analy [....] » Read More
Title : Recombinant BCG vaccine as a potent anti tuberculosis vaccine candidate
Sajal Dey, BRIC-Centre for DNA Fingerprinting and Diagnostics, India
Tuberculosis (TB) is a significant global health challenge; it has been responsible for more human lives lost than any other infectious disease. BCG is the only pre-emptive vaccine against tuberculosis. However, the variable efficacy of BCG is well acknowledged fact which prompte [....] » Read More
Title : Molecular characterization of nucleoporins–influenza A virus interactions: Potential host-directed therapeutic target
Kajal Sharma, University of Delhi, India
Influenza A virus (IAV), a negative-sense single-stranded RNA virus, primarily relies on the host nucleocytoplasmic transport machinery for trafficking of viral ribonucleoprotein (vRNP) complexes. The nuclear pore complex (NPC), composed of nucleoporins (NUPs), serves as a crucia [....] » Read More