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Aghapy Yermans Yakoup, Speaker at Vaccine Research Conference
Zewail City of Science and Technology, Egypt
Title : Characterization, antibacterial, and cytotoxic activities of silver nanoparticles using the whole biofilm layer as a macromolecule in biosynthesis

Abstract:

Recently, multi-drug resistant (MDR) bacteria are responsible for a large number of infectious diseases that can be life-threatening. Globally, new approaches are targeted to solve this essential issue. This study aims to discover novel antibiotic alternatives by using the whole components of the biofilm layer as a macromolecule to synthesize silver nanoparticles (AgNPs) as a promising agent against MDR. In particular, the biosynthesized biofilm-AgNPs were characterized using UV-Vis spectroscopy, electron microscopes, Energy Dispersive X-ray (EDX), zeta sizer, and potential while their effect on bacterial strains, and normal cell lines was identified. Accordingly, biofilm-AgNPs have a lavender-colored solution, spherical shape, with a size range of 20–60 nm. Notably, they have inhibitory effects when used on various bacterial strains with concentrations ranging between 12.5 and 25 μg/mL. In addition, they have an effective synergistic effect when combined with phage ZCSE9 to inhibit and kill Salmonella enterica with a concentration of 3.1 μg/mL. In conclusion, this work presents a novel biosynthesis preparation of AgNPs using biofilm for antibacterial purposes to reduce the possible toxicity by reducing the MICs using phage ZCSE9.

Biography:

Aghapy Yermans Yakoup is a graduate, batch 2023, with a biomedical sciences major (BMS) (medical sciences concentration) from Zewail City for Science, Technology, and Innovation. In addition, she have worked as a junior researcher assistant (jRA) in the Center for Microbiology and Phage Therapy (CMP) in Zewail City for Science, Technology, and Innovation from Fall 2021 until Summer 2023. She is working currently as an R&D specialist in Pharmaplast company. She is interested in finding new solutions to get rid of multi-drug-resistant bacteria and inventing new compounds that can be alternatives to antibiotics. Also, she is interested in the medical microbiology field. In the future, she is planning to enroll in a Ph.D. program that aims to find new applicable solutions for infectious diseases in different body systems like the nervous system and cardiovascular system.

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