Elena Chiappini, University of Florence, Italy
Background: Paediatric tuberculosis (TB) represents a critical health concern due to the significant risk of extrapulmonary TB (EPTB), severe disease forms, and the increasing prevalence of drug-resistant strains (DR-TB). Understanding the clinical characteristics of affected chi [....] » Read More
Title : Prophylactic and Molecular Approaches for Mitigating Human Influenza A Viruses: i. Evaluating influenza Vaccine Effectiveness in the Older population ii. Down-regulation of influenza virus genes with novel siRNA-chimeric-ribozyme constructs
Madhu Khanna, University of Delhi, India
Influenza viruses continue to cause severe emerging and remerging outbreaks worldwide. Recent viral pandemics of the 2009 [pandemic influenza A (H1N1)] and 2019 (SARS-CoV-2), have enhanced the need of vigilance for combating such emerging and re-emerging viral outbreaks and mitig [....] » Read More
Title : Targeting resistance: New 4-substituted pyrazolidine and isoxazolidine as antibiotics with interesting antimicrobial activities
Yousfi Tarek, Nationale Research for Biotechnology Research Center, Algeria
A series of new isoxazolidine and pyrazolidine compounds were synthesized in very good yields of 76-99.2% by Michael and Aza-Michael reactions, respectively, and all compounds were characterized by 1H NMR, 13C NMR. we discovered that the pyrrolidine/benzoic acid catalyzed in Mich [....] » Read More
Title : Development of a Novel Multi-component Vaccine to Address the Burden of Otitis Media in High-Risk Populations
Ayesha Zahid, Griffith University, Australia
Background: Middle ear infection (otitis media) remains the most common childhood disease diagnosed among Australian Indigenous children. Despite extensive antibiotic usage, it persists as a significant health concern, characterized by substantial morbidity and economic burden. S [....] » Read More
Title : Barriers to polio eradication in South Asia: A systematic review
Awranoos Ahadi, Bolan Medical College, Pakistan
Background: The Eastern Mediterranean Region (EMRO) of the World Health Organization (WHO) is the last region in which polio transmission continues. Afghanistan and Pakistan, also being parts of South Asia, pose a major burden for the transmission of the virus both in the EMRO an [....] » Read More
Title : Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia, May 2020
Temesgen Azemeraw Yitayew, Addis Ababa University, Ethiopia
Primary HPV testing and triage of HPV – positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community based screening in resource-poor communities, provided a robust tracking system is in place.&nbs [....] » Read More
Title : Awareness and Acceptability of Rotavirus Vaccine among mothers of under-five children in Gusau and Bungudu c Ommunities of Zamfara State, Northwestern Nigeria
Attahir Abubakar, Ahmadu Bello University, Nigeria
This study examines the awareness and acceptability of the rotavirus vaccine among mothers of children under five in Gusau and Bungudu, Zamfara State, Nigeria. Employing a comparative cross-sectional design, the research utilized quantitative surveys and qualitative focus groups [....] » Read More
Title : Immunogenicity and Cryo-EM structure of native-like HIV-1 Clade-C envelope trimers derived from a pediatric elite-neutralizer
Swarandeep Singh, All India Institute of Medical Sciences, India
Induction of broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine research. Elite neutralizers are rare HIV-1-infected individuals who develop broad and potent neutralizing antibody responses. Herein, we characterize a stabilized HIV-1 Clade-C envelope mimic, [....] » Read More