Myeloid cells are the major players of innate immunity and inflammation. The functionality of myeloid cells is controlled by innate immune receptor signaling, which is critically regulated by a cytoplasmic adaptor protein termed TRAF3. Ablation of TRAF3 from myeloid cells does no [....] » Read More
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of deaths and substantial morbidity worldwide, particularly in fragile subjects including dialysis patients. The continuous evolution of SARS-CoV-2 alters its pathogenicity and infectivit [....] » Read More
We haven’t heard back from you since our last conversation. Human serum albumin, a key blood plasma protein, plays an important role in vaccine production. It is not only a stabilizer, but also a basic ingredient of some preparations, which emphasizes its fundamental import [....] » Read More
The mission of the Biomedical Advanced Research and Development Authority (BARDA) as part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services, is to enhance the U.S. government’s capability to respond to chem [....] » Read More
Background: Uninterrupted availability of potent vaccines requires robust vaccine supply chain and logistics system (VSCLS). With special focus on remote and underserved settings, we assessed the reach and bottlenecks to end-to-end delivery of the Ethiopian VSCLS after the initia [....] » Read More
Dengue, a significant global health challenge, is caused by four co-circulating serotypes (DENV 1-4) of the virus. Viral infections not only result in health complications and fatalities among infected individuals, but it also depletes limited resources intended for preventing in [....] » Read More
Background: Dendritic cells (DCs) are pivotal in developing therapeutic cancer vaccine based on its function of crossing antigen presenting and induction of anti-tumor cytotoxic T lymphocyte response.1,2 To increase the efficacy of current anti-tumor DC vaccine, we developed a bi [....] » Read More
Background: Increasing attention is being given to reach children who fail to receive routine vaccinations, commonly designated as zero-dose children. A comprehensive understanding of the supply- and demand-side barriers is essential to inform zero-dose strategies in high-bu [....] » Read More
The Democratic Republic of Congo (DRC) faces multifaceted challenges in vaccine supply and logistics, hindering the efficient delivery and distribution of life-saving vaccines. This presentation delves into the complexities surrounding vaccine supply chains within the context of [....] » Read More
Background: Ethiopia is the fourth leading contributor to the global total of zero-dose children (those who lack the first dose of the pentavalent vaccine) and has substantial regional variations in zero-dose children. This study explored the spatial pattern of zero-dose children [....] » Read More
Background: Ethiopia is the fourth leading contributor to the global total of zero-dose children (those who lack the first dose of the pentavalent vaccine) and has substantial regional variations in zero-dose children. This study explored the spatial pattern of zero-dose children [....] » Read More
Background: The WHO/UNICEF estimates that over 18 million children in low- and middle-income countries, especially in Africa and South-East Asia, are not being vaccinated, with Ethiopia being one of the top four countries contributing to this issue. Objective: To estimate [....] » Read More
Monkey pox (Mpox) virus (MPXV) spreads through skin-to-skin contact, causing painful lesions. The 2022 outbreak resulted in the Congo’s worst surge on record, with the subsequent world-wide spread causing nearly 20,000 suspected cases and 820 suspected deaths. Effecti [....] » Read More
Respiratory Syncytial Virus (RSV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and influenza are prominent respiratory pathogens that significantly impact global public health. Each of these viruses poses distinct challenges and complexities, contributing to res [....] » Read More
This presentation elucidates the findings of a rigorous six-month evaluation of the Expanded Program on Immunization (EPI) conducted by the Health Department of Bahir Dar City. Utilizing a robust dataset extracted from the District Health Information System 2 (DHIS2), this analys [....] » Read More
70% of people over 65 are hypertensive; high blood pressure increases the risk of exposure to cardiovascular disease (myocardial infarction and heart failure) and stroke. This is a public health problem, given the aging of the population. There are few studies carried out in eld [....] » Read More
Human challenge trials (HCT) or controlled human infection model (CHIM), which involve purposeful or intentional exposure of infectious microorganisms to healthy human volunteers, have a long history in medicine and have contributed significantly to our understanding of the scien [....] » Read More
Attitudes toward vaccination are doubtless an important determinant of public health, and this became evident after the first year of the last COVID-19 pandemic. The issue, long-debated within European societies, especially with respect to occasional surges of diseases in given y [....] » Read More
Antimicrobial resistance (AR) is an urgent and major global public health threat, killing at least 1.27 million people worldwide and associated with nearly 5 million deaths in 2019, a report from The Lancet. In the U.S., more than 2.8 million antimicrobial-resistant infectio [....] » Read More
Porcine Circovirus Type 2 (PCV2) is a major threat to pig farming in India, with emerging PCV2d strains causing vaccine failures. This study aimed to develop a recombinant virus-like particle (VLP) vaccine targeting the Indian isolate of PCV2d capsid protein and evaluate its effi [....] » Read More
In India, many disease control programs for vaccine-preventable diseases have been running for several decades but such diseases are regularly haunting India. Why? Is it poor vaccine quality, vaccination defect or both? To understand the dilemma we may take the example of the Nat [....] » Read More
Coronavirus disease (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has resulted in 775 million confirmed cases and approximately 7 million deaths reported by the World Health Organization (WHO) as of 31 March [....] » Read More
Vaccine hesitancy has increased as pediatric immunization rates have decreased, with lowest rates for children experiencing social determinants of health. Limitations within data infrastructure and immunization information systems (IIS) for pediatrics create barriers to understan [....] » Read More
Background: Despite extensive research, an effective prophylactic vaccine against HIV-1 remains elusive. Currently, substantial focus is directed toward developing vaccines that can induce broadly neutralizing antibodies (bNAbs) capable of neutralizing multiple HIV-1 strains. How [....] » Read More
Google Trends, launched on May 11, 2006, serves as a valuable research tool across various healthcare topics. It analyzes daily Google Searches in the United States, offering geographic and temporal pattern data for searched terms (1). Instead of surveying user-stated preferences [....] » Read More
In developing nations the cost of commercial vaccines to immunize children against Polio virus, Diphtheria, Tetanus, Pertussis, Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae can be prohibitive. If one could develop inexpensive adjuvants for these ap [....] » Read More
During the COVID-19 pandemic, vaccines have produced protective immunity sufficient enough to cause a decrease in hospitalizations and deaths; however, the pandemic continues due to mutational events, predominantly occurring in the S1 sequence of the spike protein of SARS-CoV-2. [....] » Read More
In resource-constrained nations, the cost of commercial vaccines to immunize animals can be prohibitive. For example in the USA the cost of a single dose of rabies vaccine for horses is US $7. The encephalomyelitis combination vaccine for horses is US $28. Various combination vac [....] » Read More
The absence of sufficient vaccine safety information is one of the key contributors to vaccine hesitancy. In this presentation, I will discuss the methodology and findings of four of our recent studies that evaluated the safety profile of the second and third BNT162b2 mRNA COVID- [....] » Read More
Scientific Programs coming soon..