Title : Meningitis Epidemics in sub-saharan african meningitis belt from 2011 to 2023
Abstract:
Background: Bacterial meningitis epidemics remain a major public health challenge in sub-Sharan African meningitis The objective of this study is to describe the bacterial meningitis epidemics and response reported in sub-Saharan African meningitis belt from 2011 to 2023.
Methods: A retrospective analytic cross-sectional study was conducted. Cases, incidence, deaths, case fatality rates, pathogens, reactive vaccination, occurrence of bacterial meningitis epidemics were variables considered.
Results: The meningitis A conjugate vaccine rollout in countries of the African sub-Saharan meningitis belt since 2010 resulted in a significant reduction in the occurrence of meningitis epidemics, incidence of Neisseria meningitidis A cases and a change in the bacterial profile of meningitis, with a predominance of Neisseria meningitidis serogroups C, W, X. and Streptococcus pneumoniae. From 2011 to 2023 12 countries of sub-Saharan African meningitis belt experienced bacterial meningitis epidemics (Benin, Burkina Faso, Cameroun, Chad, Democratic Republic of Congo (DRC), Ethiopia, Ghana, Nigeria, Niger, Senegal, South Sudan, Togo). The number od health districts that reported epidemics varies of years. In 2017, the highest number of health districts reported epidemics (45) as follows: Nigeria (37), Niger (4), Benin (2), Togo (2), and Cameroon (1). The predominant pathogens were N. meningitidis C, W. Nigeria and Niger are the countries that reported mostly meningitis epidemics caused mainly by N. meningitidis C. Nigeria reported meningitis epidemics during 9 out of 13 years from 2013 to 2023 accepted in 2022. Whereas Niger experienced meningitis epidemics for 8 years out of 13. Ghana reported meningitis epidemics caused by S. pneumo in 2016 and 2020 while Togo experiences it in 2023. Mixed epidemics were reported by Niger in 2018 (N. meningitidis C, X) and Ghana in 2016 and 2020 (S. pneumo and N. meningitidis W) and (S. pneumo and N. meningitidis X) respectively. Strains most circulating in meningitis belt are N. meningitidis C (ST-102017), N. meningitidis W (ST C11), and S. pneumo serotypes.
Conclusion: Despite tremendous efforts made resulted to the elimination of meningitis A meningitis epidemics remain a burden. Meningococcal multivalent conjugate ACXWY rollout in sub-Saharan African meningitis belt might contribute to eliminate bacterial meningitis.