Title : Design of a multi-epitope vaccine using immunoinformatics approach
Abstract:
Immunoinformatics plays a key role in vaccine design and antibody production. In the past, antibody design and vaccine development are expensive and time-consuming. Nowadays, advances in the field of bioinformatics have provided practical tools that can be used to lessen the time and cost of vaccine and antibody design. The Immunoinformatics approach allows the identification of the immunogenic epitopes from the pathogen genomes. Also, the ideal and immunogenic parts could be developed as potential vaccine candidates to trigger protective immune responses in the hosts. In our studies, are identified the potential and immunogenic epitopes of a selected protein by bioinformatics tools. Then, these are selected based on allergenicity, antigenicity, and solubility features. And we use linkers and adjuvants to structure the epitope vaccines. Then, the 3D structure of the protein was predicted, and its affinity to different HLA, TLR was investigated by molecular docking. These methods have been performed with a wide range of bioinformatics tools to design vaccines against Covid19, Acinetobacter Baumannii, and Neisseria meningitidis. The design technique of these vaccines will be clearly mentioned in the lecture.
